Oprah Winfrey -Winfrey is best known for her multi-award-winning talk show "The Oprah Winfrey Show" which was the highest-rated program of its kind in history and was nationally syndicated from 1986 to 2011. She has been ranked the richest African-American of the 20th century, the greatest black philanthropist in American history, and was for a time the world's only black billionaire. She is also, according to some assessments, the most influential woman in the world. Winfrey was born into poverty in rural Mississippi to a teenage single mother and later raised in an inner-city Milwaukee neighborhood. She experienced considerable hardship during her childhood, saying she was raped at age nine and became pregnant at 14; her son died in infancy.
Franklin Roosevelt -Four-time President of the United States Paralyzed from the waist down by polio before running for office.
