Question

Which type of mutation results in a frameshift mutation? Check all that apply. substitution

Answer 1

Insertion and deletion result in a frameshift mutation. Frameshift mutations caused by "indel" mutations, meaning insertion or deletion mutations. These mutations shift the way the DNA is read. A frameshift mutation can throw off all of the nucleotide that follow in a DNA sequence, making them particularly likely to lead to significant consequences. 

Answer 2

A frameshift mutation is a mutation that leads to a change in the reading frame potentially changing the translation of the gene. 
Insertion and deletion are the types of mutations that may cause a frameshift mutation. By inserting or deleting a base pair or whole sequences of DNA, the reading frame is altered and if these mutations interrupt a codon or are not multiple of three then the final translation of the gene won't be the same thanks to the triplet nature of gene expression by codons.