If you're asking this question in terms of Literature, the film that is most famous for its use of synchronized sound is the jazz singer the jazz singer triggered the talking-picture revolution A year after the release of few different films, Hollywood recognized the importance of the jazz singer with regard to the motion picture history by honoring the film with an special award. :) Hope I helped!
DNA is a dynamic and adaptable molecule. As such, the nucleotide sequences found within it are subject to change as the result of a phenomenon called mutation. Depending on how a particular mutation modifies an organism's genetic makeup, it can prove harmless, helpful, or even hurtful.
Mutation (A)