1. The heme of hemoglobin releases the iron. The heme then converted into biliverdin, which is converted into bilirubin.
2. Conjugated bilirubin is excreted as is then part of the bile into the small intestine. Bacteria of the intestine break down the bilirubin.
3. Some bilirubin derivatives converted into which is contribute to the color of feces.
4. Other biliurbin derivatives are reabsorbed from the intestine into the blood. These derivatives are excreted from the kidneys and contribute to the color of urine.
5. The globin chains of hemoglobin are broken down to individual amino acids and are metabolized or used to build new proteins.
6. Blood transports free bilirubin to the liver.
7. Blood transports iron in combination with transferrin to various tissues for storage or to the red bone marrow where it is used in the production of new hemoglobin.
8. Hemoglobin is broken down by macrophages into heme and globin chains.
In a way, this is a double edged sword. On one hand, the animals are needed to best test the effects, but on the other hand it can be seen as very unethical. Honestly, I don't really see a way around using the animals. Unless you get human volunteers, but there is no way to fully make them understand what they are getting themselves into which can turn unethical very, very fast. If all of a sudden one of your human volunteers decides that they do not want to be a part of the test anymore, there is noting you can do to reverse what has already been done.
Um B? not really sure only one would say is B doesn't sound like it would because of organization
