Question

Even though cancer genomes are overall hypomethylated, explain why some genes are hypermethylated in cancer cells. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. A. DNA repair genes B. OncogenesC. Cell Cycle stop genesD. Are not expressedE. HypomethylationF. HypermethylationG. Are expressed H. protein-coding genes______promoters will lead to reduced expression of the correspondent genes. Some genes such as____and_____need to be expressed. When they______, this can lead to cancer.

Answer 1

Answer:

Hypermethylation of___ promoters will lead to reduced expression of the correspondent genes. Some genes such as Cell Cycle stop genes _and__DNA repair genes_need to be expressed. When they__are not expressed_, this can lead to cancer.

Explanation:

Oncogenes are genes that may trigger cancer, where they are generally overexpressed (i.e., expressed at high levels). Although there are well-documented exceptions to this rule, DNA methylation generally represses gene expression by preventing the binding of transcription factors to promoters. It is known that the hypermethylation of tumor suppressor genes including, for example, cell cycle stop genes and DNA repair genes, may lead to cancer. Similarly, hypomethylation of oncogenes such as, for example, Cyclin D1 (a cyclin-dependent kinase involved in cell cycle progression), may also contribute to carcinogenesis.