Answer: 24 months
Explanation:
According to John Bowlby's Attachment Theory, infants go through 4 stages of attachment which are the Pre-attachment phase, Attachment-in-making phase, Clear-cut attachment phase, and Formations of reciprocal relationships phase.
Anna is in the <em>Formations of reciprocal relationships</em> phase which kicks in at around 24 months. At this stage, infants begin to take into account the feelings of others before acting. They are able to understand what refusal means and so can try to hide things they think are wrong so as not to get into trouble.
Thomas should receive 8.71 ml per day
<h3>
Dosage</h3>
A dosage is the amount of a medicine or drug that someone takes or should take, and how ` they should take it.
1 oz = 0.0283495 kg; also 1 lb = 0.453592 kg.
Hence 15 lb 6 oz = (15 lb * 0.453592 kg/lb) + (6 oz * 0.0283495 kg/oz) = 6.97 kg
Since the dosage is 50 mg/kg/day. Hence amount of mg given is:
Amount of mg = 50 mg/kg/day * 6.97 kg = 348.5 mg per day
Each 10 ml contains 400 mg; hence:
ml = 348.5 mg * 10 ml per 400 mg = 8.71 ml per day
Thomas should receive 8.71 ml per day
Find out more on Dosage at: brainly.com/question/2559030
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
