Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
a,b,c,d,f,g are true only e is false
Explanation:
.Jóîn) __ ""(stw-aijd-bha)""__ 6x 10-1'coulomb or one unit. The ratio, mass for each of the particle is 9.58 x 10" per gram. Hence, the mass of each of this 797 1.6x 10-19 = 1.67X 1024 9.58 x 10 c/m Properties of all
Answer:
Bits
Explanation:
The protocol data unit is the representative unit of data in the OSI layer of a network. The OSI system has seven layers.
The physical layer is the first layer of the system and the protocol data unit is represented as bits of data.
Note that the term packet is the PDU for data in the network layer of the OSI network system.
Answer:
Remote Backup means the backup of your data that is stored at some online storage place or server.
Explanation:
Remote is the terminology that is used for distance things that are not directly accessible but can be accessed through some online medium.
Backup means copy your data or information that is stored some where other than your PC.
So Remote Backup is a type of server that is used to store data on some online storage or server. Some times this server is called cloud.
<u>For Example</u>
Dropbox and Google drive are the examples of the remote server, These two storage are used to backup our data online. We can store and access data through these drives by on online server or storage by just having an internet connection.
