“Genes and environmental effects are often part of the explanation. “
“...disease-causing alleles of one gene may be suppressed by alleles of another gene elsewhere in the genome, or a person's overall health may influence the strength of a disease phenotype.”
https://www.khanacademy.org/science/high-school-biology/hs-classical-genetics/hs-non-mendelian-inheritance/a/polygenic-inheritance-and-environmental-effects
The heat from hotter object goes to the cooler object. when they reach the same temperature the heat flow will stop.
Enzymes are in the Proteins class
Teperature
Ph level
Substrate concentration
Not sure if these are physical but hope it helped.
