Answer:
government that is your answer
Explanation:
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
to get the heat of the planet
Explanation:
The correct option is A ie the process whereby non-sister chromatids exchange genetic material
- Between prophase I and metaphase I, a process known as crossing over occurs in which two homologous non-sister chromatids join up and exchange various pieces of genetic material to create two recombinant chromosome sister chromatids.
- When genetic material is switched between two chromosomes, this process is known as crossing over.
- It is in charge of causing genetic variation among members of a species.
- Only the reproductive cells known as gametes undergo this process.
- The steps involved in crossing over are as follows:
1) Synapsis.
2) Chromosome duplication
3) Crossing over.
4) Terminalizataion.
Learn more about crossing over here :
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<span>The discoverers of DNA were not James
D Watson and Francis Crick. They are the first scientist to formulate an
accurate description of the DNA’s (deoxyribonucleic acid) complex ,
double-helical structure. They discovered that base pairing nucleotides must
be; adenine and thymine; and cytosine and guanine. These base pairs are held
together by a hydrogen bond, atype of chemical reaction that s easy to break
and easy to reform. The statement is “DNA
is a double helix made of two strands linked together with hydrogen
bonds.”</span>
