Question

This pedigree shows the inheritance Leber congenital amaurosis (LCA) which is a type of hereditary blindness. Individuals with this disease lose their vision during childhood. 3. What is the inheritance pattern shown?

Answer 1

About the question: You will find the pedigree in the attached files

Answer:

Autosomal recessive inheritance

Explanation:

Autosomal recessive inheritance characterizes by the expression of the recessive trait. Two copies of these alleles are needed to express the recessive phenotype and no dominant alleles.

Let us assume that the diallelic autosomal gene has a dominant allele L that expresses the normal phenotype and the recessive allele l that expresses the altered phenotype. The pedigree would be as shown in the attached files.

To interpret the pedigree, remember that

• Squares represent males
• Circles represent females
• Empty figures express normal/healthy/not affected individuals
• Solid black figures represent affected individuals