Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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1. During DNA elongation, polymerase enzyme adds new, free nucleotides to the three prime end of the newly forming strand, elongating it in five prime to three prime direction while the telomerase protects the important genes at the end of the chromosome from been deleted as the DNA strand shorten during DNA elongation.
2. During DNA elongation, helicase enzyme separates the double stranded DNA into single strand by melting the hydrogen bond that holds the DNA molecule together thus enabling each strand to be copied while the telomerase acts by preventing the telomere from been deleted during elongation.
Answer:
more information is needed, because organisms from both the bacteria and archaea domains are prokaryotic and unicellular.
Explanation:
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A sea sponge is what mimics a synthetic sponge
Answer: b. The radius forms the point of the elbow
c. The radius articulates to the wrist closest to the thumb
Explanation:
Ulna and radius are the two bones of the forearm. These bones articulates with the humerus and carpels of the hand.
b. The radius forms the point of the elbow: The elbow joint is the hinge joint that forms between the proximal ends of the radius and ulna in the forearm and distal ends of the humerus. The radius forms a pointed end.
c. The radius articulates to the wrist closest to the thumb: The wrist forms a complex joint. It forms a transition between the hand and the forearm. The radial deviation in the wrist forms the basis for the movement of the tilting of the wrist joint towards the thumb.
