Answer:
If an inhibitory synapse fires at the same time and at the same distance from the initial segment as an excitatory synapse of the same intensity there will be no changes in the potential in the firing zone.
Explanation:
Under normal conditions, the transmembrane potential depends on the ionic charges present in the intracellular and extracellular spaces. The extracellular space load is usually positive and in the cytoplasm is negative.
- <u>Depolarization</u> occurs by opening ion channels that allow sodium to enter the cell, making the intracellular space more positive.
- An opening of potassium channels releases this ion to the extracellular space, leading to <u>hyperpolarization</u>.
An excitatory synapse is one capable of depolarizing a cell and boosting the production of action potential, provided it is capable of reaching the threshold of said potential.
On the other hand, an inhibitory synapse is able to hyperpolarize the cell membrane and prevent an action potential from originating, so that they can inhibit the action of an excitatory synapse.
The interaction between two synapses, one excitatory and one inhibitory, -called synapse summation- will depend on the strength that each of them possesses. In this case, the intensity of both synapses being the same, there will be no changes in the membrane potential in the firing zone.
Learn more:
Excitatory and inhibitory postsynaptic potentials brainly.com/question/3521553
<span>Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties.
We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome.
Keywords: Rhabdomyolysis, acute renal failure, myoglobin, crush syndrome
The first case of the crush syndrome, which constitutes one of the main causes of rhabdomyolysis, was reported in Sicily in 1908, after an earthquake1,2. In 1930, in the Baltic area, an epidemic of myoglobinuria was observed due to consumption of contaminated fish. Interest in rhabdomyolysis and crash syndrome was stimulated during the World War II particularly after the bombing in London, where the victims developed acute renal failure and myoglobinuria1.
Rhabdomyolysis is a rupture (lysis) of skeletal muscles due to drugs, toxins, inherited disorders, infections, trauma and compression3. Lysis of muscle cells releases toxic intracellular components in the systemic circulation which leads to electrolyte disturbances, hypovolemia, metabolic acidocis, coagulation defects and acute renal failure due to myoglobin4.
The skeletal muscle consists of cylindrical myofibrils, which contain variant structural and contraction proteins. Actin and myosin, arranged in thin and thick filaments respectively, form the repeated functional units of contraction, the sarcomeres5. The sarcoplasmic reticulum constitutes an important cellular calcium storage. It is structurally connected to the t-tubules, that are formed by invaginations of the muscle cell plasma membrane, the sarcelemma, around every fibril (Figure 1). After the sarcelemma depolarization, the stimulation arrives, through the t-tubules junctions, at the sarcoplasmic reticulum, inducing the calcium ions release and triggering muscle contraction6.</span>
Answer: Experiment.
Explanation:
Suppose that we have two related variables, A (independent) and B (dependent)
We could design an experiment where we can manipulate the value of A at will, and we also can observe how the variable B changes.
This is called an experiment, where the objective is to see how the variable B is related to the variable A, and then try to make a model that explains this relationship.
