SCA is a common monogenic blood disorder with potentially devastating consequences due to chronic and episodic disease; it has a massive impact on the health-care system and is linked to a significant reduction in life span.
We show that gene therapy with a lentivirus vector expressing γ-globin has the potential for a one-time cure and define the parameters required to cure the disease. We also show a preclinical in vivo method for determining the minimal amount of genetically corrected hematopoietic stem cells needed to correct disease, which is important in the design of clinical gene therapy trials.
The expression of the γ-globin gene in hematopoietic stem cells (HSCs) results in enough postnatal fetal hemoglobin (HbF) to correct sickle cell anemia (SCA) in the Berkeley "humanized" sickle mouse. We assessed critical parameters for correction after de-escalating the number of transduced HSCs in transplant recipients using reduced-intensity conditioning and varying gene transfer efficiency and vector copy number.
The minimal amount of HbF, F cells, HbF/F-cell, and gene-modified HSCs required for correcting the sickle phenotype was determined using a systematic quantification of functional and hematologic red blood cell (RBC) indices, organ pathology, and life span.
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I think most probably that the gas is NITROGEN as it's converted to manure by some microorganisms also that's very gud for plants grownth
Answer:
Bulk flow
Explanation:
Generally when there is mass movements of molecules of the fluids from a high pressure gradients to low pressure gradients; that is down the concentration gradients, the process is called Bulk flow. In relation to cells, it is the exchange of material between cells through the pores of the adjoining cells. In xylem , water and minerals flow from high pressure roots to the leaves, and phloem transport food substances from the leaves the sources at high pressure to other parts of the plants.
The capillary transport mechanisms involves the movements of fluids, ions across the fenestration of the capillaries due to the hydostatic pressure of the fluid from the high pressure to the low pressure cellular environments.This is common in the glomerulus of the kidney, intestine, and some endocrine glands.
The single wall endothelial lining of capillaries forms continuous wall which allows passage of ions and fluids while restricting movements of large molecules. Generally the high pressure from the hydrostatic pressure forces these materials across the walls.
Simple diffusion which follows concentration gradient across membranes ensures distribution of substances across the walls for fast uptake by the cells.
The movement of Macromolecules across capillary wall is called vesicular transport.
Thus Bulk flow is odd.
<span>It enhances excretion of bile leading to increased cholesterol turnover.</span>
Answer: Stratum Corneum
Epidermis. The epidermis is the thin outer layer of the skin. It consists of 3 types of cells: Squamous cells. The outermost layer is continuously shed is called the stratum corneum
Explanation:
stratum corneum
The epidermis has no blood supply and depends on diffusion from the dermal cells for its metabolic needs. The dead-cell layer of the stratum corneum provides the protection from water loss that allows vertebrates to dwell on land
