Rufus Putnam, was the first settler who went into the Ohio Valley <span>September 29, </span>1789.
<span>The first recorded appearance of the plague in Europe was at Messina, Sicily in October of 1347. It arrived on trading ships that very likely came from the Black Sea, past Constantinople and through the Mediterranean. While Sicily was succumbing to the horrors of the disease, the expelled trading ships brought it to other areas around the Mediterranean, infecting the neighboring islands of Corsica and Sardinia by November.</span>
