Answer and explanation;
-The insulin receptor itself has decreased kinase activity leading to fewer binding sites for singling effectors to become activated.
Therefore; the signaling effectors are less likely to be activated.
-Additionally,, feedback inhibition decreases signaling effector binding to receptor.
-The lack of activation of these initial signaling effectors prevents any subsequent steps from happening.
-We can thus conclude this by saying that higher insulin concentrations are necessary to obtain the same level of signaling leading to physiological effects that would exist in someone without type-2 diabetes.
-Also the requirement for higher insulin concentration means that the cells that respond to insulin are resistant to its effect.
It would be best to use an MRI to check for any torn ligaments.
Hope this helps :)
Answer:
As the amount of impervious paved surfaces increase, watersheds become more vulnerable to pollutants. When rains fall on a conventionally paved impervious surface, the precipitation is generally directed down storm drains, which can result in flooding and overwhelming the storm water management system.
Explanation:
The temperature increases as you go deeper in the aquatic system.
