The total amount of sea ice showed a decline from 2012 to 2019. The correct option would be D.
<h3>Graphical illustration</h3>
Looking at the graph, from February to June 2012, there is a decline in the amount of sea ice.
A similar decline in the amount of sea ice can be observed in the year 2019.
However, the sea ice levels for the various months in 2012 remain generally above the sea ice levels in the various months in 2019.
Thus, overall, one can say there is a general decline in the ice level from 2012 to 2019.
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Rabbit ear size tends to decrease as latitude increases. this is an example of a cline
.
A cline can be described as a change of the biological trait of a species across its geographical range. A cline can be genetic for example, change in the allele frequency, or phenotypic (change in body size). The change can be shown as continuous gradation, or it can be more abrupt from one geographic region to the next.
The United States Constitution is the world's longest continually operating written charter of governance. It was prepared in 1787, adopted in 1788, and entered into force in 1789.
The first three words of it, "We The People," indicate that the American government's goal is to serve its people.
<h3>What form of government evolved in the aftermath of the American Revolution?</h3>
The powers of the national government were specified in the Articles of Confederation following the United States' declaration of independence from Great Britain.
In order for the Constitution to be ratified by all 13 states, the participants in the Constitutional Amendment had to reach a number of agreements.
Thomas Jefferson authored the Declaration of Independence in 17 days. On July 2, 1776, Congress resolved to secede from the United Kingdom. On July 4, 1776, Congress approved the Declaration of Independence, which became known as Independence Day.
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Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
