Sympathetic-adreno-medullar (SAM) axis, secretes noradrenaline and norepinephrine and the hypothalamus-pituitary-adrenal (HPA) axis, secretes glucocorticoids during stress.
SAM (Sympathetic-adreno-medullar) axis activation occurs in just a seconds as a result of a stressor and generate a adaptive respond towards stressor. The HPA axis is a slower response system involving release of corticosteroids .
Corticosteroids are corticotropin releasing hormone, adrenocorticotropic hormone, and cortisol, Which suppress the immune system . Corticotropin-releasing factor (CRF) plays a major role in the stress response by regulating the hypothalamic-pituitary-adrenal (HPA) axis.
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