The answer to the question is True
1. if the person is saying goodbye to everyone and saying sorry and how much they love them
2. if they write a note
3. when the person starts giving up on everything
4. if the person is drowning in self pity they tend to think suicidal
5. signs of being depressed or emotional outburst for no reason
With any medicine your body becomes more tolerant, so I would say yes
