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I agree, They have been doing it..Im so lucky I never dowloaded the file and just reported them.
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An organ that makes hormones that are released directly into the blood and travel to tissues and organs all over the body. Endocrine glands help control many body functions, including growth and development, metabolism, and fertility. Some examples of endocrine glands are the pituitary, thyroid, and adrenal glands.
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yea
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Okay
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Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
In a 5-year-old child is receiving dactinomycin and doxorubicin therapy after nephrectomy for wilms tumor. The intervention that the nurse include when planning care is: Demonstrating Meticulous Oral Hygiene.
<h3>What is oral hygiene?</h3>
Oral hygiene can be defined as the way of taking care of your mouth by brushing your teeth on a daily basis so as to prevent bacteria or disease.
Carrying our oral hygiene is important when taking drugs that can tend to have negative effect on a person oral mucosa and on of the side effect of doxorubicin is thrombocytopenia.
Therefore In a 5-year-old child is receiving dactinomycin and doxorubicin therapy after nephrectomy for wilms tumor. The intervention that the nurse include when planning care is: Demonstrating Meticulous Oral Hygiene.
Learn more about Oral hygiene here:
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1) nursing vocabulary,2)mental disorder 3)DSM-5 4)subsatnce abuse
hope this is helpful
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