Answer:
I think its D but dont take my advice!!
Explanation:
The smallpox epidemic.
The millitary invasion was devastating but not to the extent of smallpox.
The Jesuits did not really devastate the New World.
Enslavement for sugar plantations mostly occurred with Africans.
Smallpox, brought in by the Columbian Exchange, had a widespread impact that killed a large portion of natives in the Americas.
So the Smallpox epidemic is the answer.
The answer is B - Ohio
Hope this helps!
