"When there are multiple mutations in a gene" is the one among the following choices given in the question that <span>is a mutated gene most likely to be passed along to offspring over several generations. The correct option among all the options that are given in the question is the second option or option "B".</span>
Answer and Explanation:
The Huntington disease is caused by a mutation in the gene that codifies for the Huntingtin protein (Htt). The mutation produces an altered form of the protein leading to the neuron´s death in certain areas of the brain.
The Huntington disease characterizes for being,
- Hereditary, passing from generation to generation. To express the disease, a person must have been born with an altered gene.
- Autosomal, affecting men and women equally, because the mutated gene is located on an autosomal chromosome.
- Dominant, which means that by getting only one copy of the altered gene coming from any of the parents, the receiving person will express the disease. The mutation in the gene dominates over the normal gene copy.
- Expressed by heterozygosis. Most people affected by the disease are heterozygous, with a normal copy and a mutated copy.
There are just a few cases all around the world (3% approximately) in which the disease is expressed with no family history. The progenitors are not affected by the mutation. These cases are very rare and are called <u>"de-novo" mutations.</u> A new mutation is spontaneously produced and it is not inherited from any of the parentals. It consists of an increase in the number of CAG repetitions. In a normal person, the number of CAG repetitions is less than 35. When there are 40 or more repetitions it occurs the disease. But when there are between 35 and 39 repetitions, the penetrance of the disease is incomplete. This is a "gray zone". Those alleles that fall in the gray zone are unstable and might produce the HD. Individuals with these unstable alleles have a tendency to increase the number of repetitions from generation to generation until the number reaches 40 repetitions and the person expresses the disease. This <u>usually occurs in the paternal germinal line</u>, as it is particularly unstable in sperm and probably meiosis greatly affects their instability, causing an increase in the number of CAG repeats.
A common human, they go from an embryo then develop into an infant then grow to a teen. once a teen they might go through changes...
a plant is also evidence, they develope from a seed to a small bud and grow to a small plant.
B. trenches .......................
These are known as Hormones. Hormones are chemical messengers that are released in one tissue normally endocrine glands for example, adrenal glands, pituitary glands, and transported in the blood stream to alter the activities of specific cells in other tissues. Hormones serves as messengers, controlling and coordinating activities or processes such as growth, metabolism and fertility in the body.
