When exposed to smoke, hydrogen cyanide may play a role in rendering firemen and bystanders incapable of performing self-rescue.
HCN is a toxin that spreads throughout the body; it is hazardous because it inhibits cytochrome oxidase, which stops cells from using oxygen. Loss of awareness, respiratory arrest, and finally death arise from inhibition of the last stage of electron transport in brain cells.
Higher HCN exposures cause cardiovascular collapse, tremors, cardiac arrhythmia (which may not manifest for two to three weeks after the fire exposure), coma, respiratory depression, and respiratory arrest. Inhaling minute concentrations of hydrogen cyanide can result in headaches, weakness, nausea, and vomiting. Larger doses might result in fainting, convulsions, gasping, fast pulse, irregular heartbeat, and even death. In general, the severity of the symptoms increases with the seriousness of the exposure.
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Ivan 1 or Ivan Danilovich also known as Ivan Moneybag or in
Russian Ivan Kalita was the grand prince of Moscow and the grand prince of
Vladimir who was known for policies that increased Moscow's power and
transformed it into the richest principality in northeastern Russia. He had a
reputation for thrift and financial shrewdness that earned him the nickname “Kalita”
or “Moneybag”. Instead of conquering territory, he preferred to purchase. He
also made Moscow the spiritual center of the Russian lands by forming a close
alliance with the metropolitan of the Russian Orthodox Church.