The type of mutation that would cause the most dramatic change in the polypeptide or protein product of a certain gene is the base-pair deletion. A deletion is a mutation in which the part or the base is lost during the process of replication. Any number of nucleotides can be deleted from a single base to an entire piece of chromosome.
He received a lot of rejections also he faced intense criticism by the church but however it was accept by a large number of scientist. Hope it helps! God bless you <span />