Answer:
the concentration of misfolded proteins would be higher than normal.
Explanation:
Chaperones proteins are required for the correct protein folding of proteins. These proteins were first discovered in bacteria. The level of chaperones is increased under thermic stress conditions, it is for that reason that they are also known as heat shock proteins (Hsp). For example, Hsp70 is a chaperon protein constitutively expressed under stress conditions that is involved in the folding of protein precursors and the refolding of misfolded proteins. In humans, Hsp70 is encoded by the HSPA1A gene, and its increased expression level is related to different health problems including neurodegenerative diseases, cerebral ischemia and epilepsy.
Diaphragm...is the muscle that helps in respiration.....there are also some other but....you said flat so diaphragm !
B. Semi fluid substance called the cytosol
Nerve that supply bone accompany blood vessels through the nutrient foramen. They are responsible for the innervation of the bone as well as its outer covering, the periostem, the inner lining of the medullary cavity, the endosteum, and the medullary cavity. The nerves that innervates these structures are mainly sensory nerves that signal injuries to the skeleton.
Blood vessels enter the bones from the periosteum through the nutrient foramen (a small opening or hole in the bone), where the nutrient artery enters and where one nutrient veins exists in bone. The blood vessels supply nutrients and oxygen required by cells and remove the waste products from the cells of the bones.
Endosteum functions to cover and lines the bone, it is an incomplete layer of cells that covers all internal surfaces of the bone within the medullary cavity. It contains the Osteoprogenitor cells, osteoblasts and osteoclasts which are important cells of the bone.
Periosteum on the other hand is a fibrous, thick membrane covering the external surface of the bone, apart from the articular cartilage on the epiphysis. It is made of two layers: the outer fibrous layer of dense irregular connective tissues that protects the bone from external structures, anchors the blood vessels and nerves to the surface of the bone. It also serves as an attachment site for ligaments and tendons. The inner cellular layer contains various cells which includes the osteoprogenitor, osteoclasts and osteoblasts.
