Question

Why is the 3-dimensional shape of a macromolecule (ex: protein) important to know from the perspective of understanding

Answer 1

Answer:

A, B and C may be true

Explanation:

The three-dimensional structure (3D) of a protein, also known as tertiary structure, is critical to its function. In general, the 3D protein structure consists of alpha-helix and beta-sheets (secondary structures) associated through disordered coiled-coil regions. Genetic mutations may cause modifications in the 3D protein structure by modifying amino acids that are added to the growing polypeptide chain during the process of translation. In consequence, the relationships among amino acids (i.e., the intermolecular attractive forces that hold them together) may also be altered by these mutations. In general, mutations that generate amino acid changes at the active site of the enzyme will have a deleterious effect, thereby decreasing or inactivating protein function. However, there are situations where a mutation may be beneficial and can eventually increase the rate of reaction of a protein.