The effect Colchicine might have on dividing cells is that the duplicated chromosomes might not be able to segregate into daughter nuclei.
Colchicine is an alkaloid that attaches to tubulin and prevents it from polymerization to microtubules. As we know that Microtubules are a component of the cytoskeleton of a cell that aids in molecular mobility inside the cell.
During cell division, chromatin condenses into chromosomes, which are then connected to microtubules. The chromosomes are separated into daughter cells by microtubules.
When these cells are treated with colchicine, tubulin polymerization to microtubules may not occur, and the chromosomes containing daughter nucleic might not be separated.
Learn more about chromosomes here:
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Answer:
The law of independent assortment states that the different genes get separated independently of each other and gets assorted into gametes to produce different combination of genes.
It was formulates by famous scientist G. Mendel based on his work on peas.
For example, in a traditional dihybrid cross of true breeding round and yellow seed plant with wrinkled and green seed plant, F2 generation show four different combinations of phenotype:
- round and yellow
- round and green
- wrinkled and yellow
- wrinkled and green
It shows that genes for round and yellow were independently inherited and genes for wrinkled and green were independently inherited. Else, new combinations could not be observed.
Homologous recombination is an event that takes place in prophase I during meiosis. The genetic material is exchanged between the non-sister chromtids of homologous chromosomes. It adds into the genetic variation within a population by producing more combination of genes in the gametes.
It does not violate the law of independent assortment as the genes were independently assorted. It only helps in producing more combinations of genes.
