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tia_tia [17]
3 years ago
14

Anthony Hoffnagle was well until after 6 months of age when he was hospitalized for pneumonia 5 times in the same year. A consul

tation with an immunologist revealed normal numbers of B cells and T cells, slightly elevated IgM, and a marked decrease in IgG and IgA. He was diagnosed with X-linked hyper IgM syndrome. Based upon the information in the previous questions, what is the most important gene that might be defective that would result in lack of class switch to IgG or IgA
Biology
1 answer:
sukhopar [10]3 years ago
3 0

Answer:

CD40L  

Explanation:

The CD40 ligand (CD40L) protein is a transmembrane glycoprotein which is expressed on activated T cells and belongs to the tumor necrosis factor (TNF) superfamily. The hyper IgM syndrome is caused by mutations in the CD40L gene, where the defective protein can no longer bind CD40 on antigen-presenting cells. The X-linked Hyper IgM syndrome is characterized by abnormal levels of immunoglobulins, i.e., low levels of IgG and IgA, and increased/normal levels of IgM. Because CD40L gene is located on the X chromosome, this disorder is observed much more frequently in males than in females.

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Klio2033 [76]
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6 0
3 years ago
In humans, six fingers (f) is the dominant trait; five fingers (f) is the recessive trait. if the father is heterozygous for six
rodikova [14]

The probability of the offspring of a heterozygous father and homzygous mother having five fingers is 50%.

<h3>How to calculate genotype of a cross?</h3>

According to this question, a gene coding for the number of fingers in humans is involved. The allele for six fingers (F) is the dominant trait while the allele for five fingers (f) is the recessive trait.

If a cross between a heterozygous father that posseses a genotype of Ff and a homzygous mother that posseses a genotype of ff, the following offsprings will be produced:

  • Ff
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  • ff
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This shows that the probability of the offspring of a heterozygous father and homzygous mother having five fingers is ½ (50%).

Learn more about genotype at: brainly.com/question/12116830

#SPJ1

3 0
2 years ago
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4vir4ik [10]
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3 years ago
Which term refers to a solution with more molecules outside the cell than inside the cell
bazaltina [42]
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3 0
3 years ago
The Punnett square shown presents a cross between two piranhas. Both parents have large teeth.
Llana [10]

Answer:

The correct answer would be C)  75% large-toothed and 25% small-toothed.

It can be explained with the help of the law of dominance which states that the dominant allele expresses itself completely over the recessive allele in the heterozygous condition.

So, the genotype TT, as well as Tt, will result in the production of dominant trait or character in the offspring.

Thus, three (1 TT and 2 Tt) out of four offspring would have large teeth and only one offspring (tt) would have small teeth.

Hence, we can conclude that 75% of the offspring will have large teeth and only 25% will have small teeth.

8 0
3 years ago
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