Blood coagulation can be triggered by vascular devices including stents, hemodialyzers, and membrane oxygenators; as a result, systemic anticoagulants are frequently needed to prevent specific intravascular thrombotic/embolic events or extracorporeal device failure. Vascular device surface-initiated thrombus development has been demonstrated to be significantly influenced by coagulation factor (F)XII of the contact activation system. Targeting the contact activation system shows promise as a substantially safer method than conventional antithrombotic for avoiding vascular device-associated thrombosis because FXII is not required for hemostasis. Create and describe anti-FXII monoclonal antibodies that block the activation or activity of the enzyme. Methods: In FXII-deficient animals, monoclonal antibodies against FXII were produced, and their binding and anticoagulant abilities were examined in purified plasma systems, whole blood flow-based tests, and an in vitro experiment.
thrombus development caused by a vascular device in a living non-human primate animal. Results: Over 400 candidates were selected from an FXII antibody screen and tested in binding and clotting experiments. Six inhibitor antibodies and one non-inhibitor antibody were chosen for functional test evaluation. The most effective inhibitory antibody, 1B2, has been shown to lengthen clotting durations, inhibit fibrin development on collagen under shear, and inhibit platelet deposition and fibrin formation in an extracorporeal membrane oxygenator used in a non-human primate. Conclusion: Selective contact activation inhibitors have the potential to be helpful research tools as well as secure and efficient thrombosis inhibitors for vascular devices.
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Bacteriuria or Asymptomatic Bacteriuria (ABU) is not a common condition or children. If the nurse is asked to obtain a urine sample from a school-age child for a urine culture to detect bateriuria, the nurse should implement the following interventions:
1. The nurse should obtain an early morning sample of urine as it gives the accurate results.
The child should not be allowed to drink water before giving the sample as water dilutes the bacterial count of the urine and might give false report.
3. There are chances of contamination of the sample and the urine might change its characteristics in a given period of time. Thus, the urine sample should be brought immediately to the laboratory for urine culture.
Answer:
BENEFITS:
The Descriptive investigation is used to describe a natural system when nothing or very little is known about the system. Like observing a new specimen in the microscope and describing it by observing the specimen.
A comparative analysis is used to compare two or more variable in nature by collecting data like observing the different colors of the rocks. It provides the data to show the similarity and dissimilarity of the population.
The Experimental investigation is used where experiments are performed to test and answer the scientific questions. The advantage is that data can be used as evidence for future research.
LIMITATIONS:
<u>descriptive method of investigation
</u>
It cannot be used to correct variable or be used to determine causes and effect of the problem
<u>experimental method of investigation
</u>
It might create an artificial situation that do not always represent the real life situation
<u>comparative method of investigation
</u>
It is not easy to control other variables that might influence the study
<em>Ngl, I just copy and pasted these answers from another brainly question</em>
Answer:The answer is tiny organisms known as cyanobacteria, or blue-green algae.
Explanation:
These microbes conduct photosynthesis: using sunshine, water and carbon dioxide to produce carbohydrates and oxygen increase. Additionally, some sources you could use that I used to answer this question was
https://www.scientificamerican.com/article/origin-of-oxygen-in-atmosphere/