Circadian rhythms are biological changes that occur on a 24 hour cycle. The correct option among all the options that are given in the question is the last option or the fourth option. This is the type of system that happens in plants, animals, cyanobacteria and fungi. I hope the answer comes to your help.
It messes up the cellular system and may mix with others
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They could set up a fundraiser, or an awareness campaign in order to inform the public about the disease. (something similar to the Ice Bucket Challenge)
I hope this helps! :)
