Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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The correct option is A.
Proactive interference refers to the tendency of the knowledge that one had learned previously to prevent one from subsequent learning. Thus, proactive interference is the difficulty that comes with learning new things due to the stuffs that one had learned before. For instance, an individual may find it difficult to learn Spanish because he has previously learn German.<span />
Hemoglobin is the protein inside red blood cells that carries oxygen. Red blood cells also remove carbon dioxide from your body, transporting it to the lungs for you to exhale. Red blood cells are made inside your bones, in the bone marrow. They typically live for about 120 days, and then they die.
Two paths carbon a benefit of using dioxide can take through renewable energy sources the carbon cycle what is
Answer:
B) Curve B represents how water takes longer to heat and longer to cool.
Explanation:
Water takes longer to heat and cool than land, you can go swimming in the begging of winter and still have warm pool. Water represents B because it takes so long to heat and cool. This can be proved because it takes longer to heat water than to cook most dry foods in the microwave.
