This happens early in embryonic development in females, where one of the two X-Chromosomes is randomly (and permanently) inactivated, as you said, in cells other than egg cells.
This phenomonon is actually called X-Inactivation.
X-Inactivation make sure that females, just like males, have a single functional copy of the X Chromosome in each and every one of their cells in their body.
Glad I could help, byee now
Answer:
Citrate Synthase facilitates the formation of citrate by deprotonating Acetyl CoA and by protonating the carbonyl oxygen of oxaloacetate
Explanation:
Citrate synthase is a key enzyme in the citric acid cycle that functions to catalyze the formation of citrate from oxaloacetate and acetyl-CoA: acetyl-CoA + oxaloacetate + H2O >> citrate + CoA-SH (Coenzyme A ). This enzyme contains three amino acids at its active site that work together to catalyze the conversion of acetyl-CoA and oxaloacetate into citrate. This active site acts by abstracting (deprotonating) a proton from the alpha carbon of Acetyl CoA which serves as the nucleophile. Subsequently, the active site of the enzyme also protonates the carbonyl oxygen of oxaloacetate, which then suffers nucleophilic attack and thereby facilitating nucleophilic substitution reaction.
