Answer:
In this study, we tested the effects of NEAA-deprived diets and checkpoint inhibitor anti-PD-1 and anti-PD-L1 in colon cancer using syngeneic mouse model (Balb/c) bearing tumors of mouse colorectal cancer cell line CT-26. Three diets were tested, including a natural rodent diet Teklad ENVIGO Global 16% Protein Rodent Diet (control 1), a formulated NEAA-complete diet COMPLETE (control 2, using amino acid mix in place of protein), and a formulated NEAA-deprived diet FTN203 (treatment, using amino acid mix in place of protein). Both COMPLETE and FTN203 have the same nutritional structures, contain 17% w/w protein equivalent, and are isocaloric. After tumor size-based randomization, these diets were provided to mice ad libitum throughout the whole test. Each of these diets was used alone or combined with anti-PD-1 antibody (i.p., twice per week for 2 weeks) or anti-PD-L1 antibody (i.v., twice per week for 2 weeks).
Explanation:
Answer:
In the West, slavery was viewed primarily around three different ideological considerations:
An abolitionist position, which advocated for the total termination of slavery and the liberation of slaves throughout the territory, seeking to guarantee the full enjoyment of the natural rights of African Americans;
A pro-slavery stance, which defended the existence of slavery based on an "inherent inequality" between whites and other ethnic groups, which served as a justification for the exploitation of the latter in favor of the former;
And finally, an intermediate position, which neither defended nor rejected slavery, but left it to the citizens of each territory to decide whether they wanted slavery to operate in their territory or not.
