, Answer:In 1838 and 1839
Explanation:
as part of Andrew Jackson's Indian removal policy, the Cherokee nation was forced to give up its lands east of the Mississippi River and to migrate to an area in present-day Oklahoma. The Cherokee people called this journey the "Trail of Tears," because of its devastating effects.
Answer:
Leptin
Explanation:
People that struggle with obesity and weight, hormones often affect their overall health. Excess body fat can cause problems with weight and hormonal issues. Leptin is one of the hormones directly connected to body fat and obesity.
Leptin is a hormone released from the fat cells located in adipose tissues, sends signals to the hypothalamus in the brain. The hormone helps regulate and alter long-term food intake and energy expenditure, not just from one meal to the next. The primary purpose of leptin is to help the body maintain its weight.
Leptin is sometimes called the satiety hormone. It helps prevents hunger and regulate energy balance, It does not allow the body trigger hunger responses when it does not need energy.
They are important because they can be harmed
The purchase gave the U.S. control of the Mississippi River and the port city of New Orleans, both of which were used by farmers to ship their crops and get paid. It also helped get rid of one country that might try to harm the new nation because France sold all their North American territory.<span />
