If a proteins shape was changed it may be able to do its function to do being unable to fit in all blood vessels/arteries and the shape change may of hindered its capability of carrying nutrients it needs to transport, etc.
for example:
If a hemoglobin (red blood cell) shape changed, (this is normally called sickle cell) the red blood cell would be to unable to travel through the body with ease and easily clog bloodstreams. Also, the hemoglobin will not be able to transport as much oxygen throughout the body.
Answer: Parkinson’s disease
Explanation: This is a result of a lack of dopamine in the brain.
It can be the beginning of "starting to think to know what the other person thinks". When people know each other for a long time, they often think they know what the other person thinks or knows. This leads to the idea that if they can complete the sentence of another person in certain cases, they will be able to do so in all cases. This is however not necessarily true.
That's rather harsh, what did they do?
(I suppose they could try watching shows with modern humor in them, that might help...)
B. because a hematologist deals with blood