The trauma support is needed by the patient as per case to case. But the basic care needed by patient and trauma care is started before the patient even gets to the hospital. Rescue professionals often respond to a call and offer pre-hospital treatment. Basic life support (BLS), advanced cardiac life support (ACLS), and paediatric advanced life support are the three main pillars of pre-hospital care (PALS).
Similar to this, pre-hospital trauma life support is used in practice to apply fundamental principles of trauma care (PHTLS). To better anticipate the symptoms that patients will present with upon arrival, the hospital personnel has to be aware of the strengths and weaknesses of the local rescue teams. The hospital staff should start triaging the patient as soon as a call from the field comes in based on their age, mechanism of injury, coagulation status, and other characteristics that can affect the care of the case.
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The binding of Beta-lactam antibacterial drugs to proteins in cell membranes cause <u>bacterial lysis and cell death.</u>
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β-Lactam antibiotics inhibit bacteria by binding covalently to PBPs in the cytoplasmic membrane. These target proteins catalyze the synthesis of the peptidoglycan that forms the cell wall of bacteria.
β-lactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
The peptidoglycan layer being the outermost and primary component of the wall. Alterations of PBPs can lead to β-lactam antibiotic resistance.
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