Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Electron transport trains create a concentration gradient of hydrogen ions outside the mitochondria and fewer inside the mitochondria and creates energy(ATP) by diffusing the hydrogen ions back in
Petiole, hopefully this helps you
The answer is epididymis.
Epididymis is a tightly coiled mass of thin tubes that carries sperm from the testes to the ductus deferens in the ale reproductive system. Sperms matures as they pass through the epididymis so that they are ready to fertilize ova by the time they enter the ductus deferens. During the ejaculation stage of emission sperms are moved from the testes and the epididymis, where they are stored, to the beginning of urethra.
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sorry man i dont know how to answer this one on brainly
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