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tankabanditka [31]
3 years ago
10

Help please and thank uu​

Biology
2 answers:
Anna [14]3 years ago
8 0

Answer:

hfa-epep-uxi

j0!n me pls

I promise there will be nothing inappropriate or unsafe

Explanation:

salantis [7]3 years ago
5 0

7.c

8.b

9.a

10.no answer

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What are the landmarks necessary for processing rna in eukaryotes?
professor190 [17]
I hope u will love it...

Eukaryotic mRNA Processing

Unlike prokaryotes which have one RNA polymerase that makes all classes of RNA molecules, eukaryotic cells have three types of RNA polymerase (called RNA pol I, RNA pol II, and RNA pol III), and each type of RNA is made by its own polymerase:

RNA polymerase I makes ribosomal RNA (rRNA)
RNA polymerase II makes messenger RNA (mRNA)
RNA polymerase III makes transfer RNA (tRNA)

Moreover, RNAs are made in the nucleus of a eukaryotic cell, but function in protein synthesis in the cytoplasm. Unlike prokaryotic mRNAs, eukaryotic mRNAs undergo extensive modifications after synthesis by RNA polymerase II. These changes include capping,polyadenylation, and splicing.

Capping

Modification of the 5'-ends of eukaryotic mRNAs is called capping. The cap consists of a methylated GTP linked to the rest of the mRNA by a 5' to 5' triphosphate "bridge"(Figure 28.30). Capping occurs very early during the synthesis of eukaryotic mRNAs, even before mRNA molecules are finished being made by RNA polymerase II. Capped mRNAs are very efficiently translated by ribosomes to make proteins. In fact, some viruses, such as poliovirus, prevent capped cellular mRNAs from being translated into proteins. This enables poliovirus to take over the protein synthesizing machinery in the infected cell to make new viruses.

Polyadenylation

Modification of the 3'-ends of eukaryotic mRNAs is called polyadenylation (Figure BR). Polyadenylation is the addition of several hundred A nucleotides to the 3' ends of mRNAs. All eukaryotic mRNAs destined to get a poly A tail (note: most, but not all, eukaryotic mRNAs get such a tail) contain the sequence AAUAAA about 11-30 nucleotides upstream to where the tail is added. AAUAAA is recognized by an endonuclease that cuts the RNA, allowing the tail to be added by a specific enzyme:polyA polymerase.

Splicing

Eukaryotic genes are often interrupted by sequences that do not appear in the final RNA. The intervening sequences that are removed are called introns. The process by which introns are removed is referred to assplicing. The sequences remaining after the splicing are called exons. All of the different major types of RNA in a eukaryotic cell can have introns. Although most higher eukaryotic genes have introns, some do not. Higher eukaryotes tend to have a larger percentage of their genes containing introns than lower eukaryotes, and the introns tend to be larger as well. The pattern of intron size and usage roughly follows the evolutionary tree, but this is only a general tendency. The humantitin gene has the largest number of exons (178), the longest single exon (17,106 nucleotides) and the longest coding sequence (80,781 nucleotides = 26,927 amino acids). The longest primary transcript, however, is produced by the dystrophin gene (2.4 million nucleotides).

RNA-DNA Hybridization Reveals Spliced-out Introns

RNA splicing was discovered during analysis of adenovirus mRNA synthesis. In these studies, the abundant viral mRNA encoding the major virion capsid protein, called hexon, was isolated by gel electrophoresis of cytoplasmic polyadenylated RNA. To map the region of the viral DNA coding for hexon mRNA, researchers hybridized the isolated mRNA to the coding strand and the RNA-DNA hybrid was visualized in the electron microscope (Figure BL). Three loops of single-stranded DNA (A, B, and C) were observed; these correspond to the three introns in the hexon gene. Since these intron sequences in the viral genomic DNA are not present in mature hexon nRNA, they loop out between the exon sequences that hybridize to their complementary sequences in the mRNA.

Similar analyses of hybrids between RNA isolated from the nuclei of infected cells and viral DNA revealed RNAs that were coliner withe the viral DNA (primarly transcripts) and RNAs with one or two of the introns removed (processing intermediates). These results, together with the findings that the 5' cap and 3' poly-A tail of mRNA precoursors are retained in mature cytoplasmic mRNAs, led to the realization that introns are removed from primary transcripts as exons are spliced together. For short transcription units, RNA splicing usually follows cleavage and polyadenylation of the 3' end of the primary transcript. But for long transcription units containing multiple exons, splicing of exons in the nascent RNA sometimes begins before transcription of the gene is complete.

Splice Site in Pre-mRNAs Exhibit Short, Conserved Sequences

5 0
3 years ago
What part of the brain is responsible for monitoring incoming information and alerting higher brain areas?
Lerok [7]

The right answer is the reticular activating system (RAS).

The Reticular Activation System. This is an element of your brain that is useful for capturing your attention and for achieving your goals more easily.

Let's take an example immediately to illustrate what the RAS really means: A loudspeaker announces your name and asks you to pick up your daughter at the reception. And there, your brain, your RAS gets in motion: your attention is at its highest level and you distinctly and clearly distinguish the message and its content addressed to you.

Thus, thanks to the RAS, which starts automatically in your brain, the relevant information is brought to your attention. The RAS plays a role of intermediary, a filter between the conscious part and the unconscious part of your brain. The latter can not store all the information, it is necessary that a relevant sorting is done between them. It's the RAS that does it. It is he who decides what is worthy of attention and what is not. As soon as it judges that information concerns you to the highest degree, he will "wake up" your brain that will absorb it. Thus, as part of our example, the RAS has been instructed to wake up your attention as soon as your name is spoken in the speaker.

8 0
3 years ago
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