The answer is Ingested corrosives may be diluted by drinking 4–6 oz (113.4–170.1 ml) of water or milk. If vomiting is persistent, do no attempt to administer additional fluids. Avoid neutralization therapies as the resultant exothermic reaction may cause additional tissue injury.
Explanation :
- Strong acids, corrosive agents, and highly reactive oxidants can cause large-scale destruction of living cells through direct chemical reactions. Sometimes referred to as necrotic cell death, this non-specific effect is induced by concentrated solutions of caustic and caustic chemicals that cause indiscriminate cell destruction.
- A generalized overwhelming effect of this type is no different from those resulting from "burning" tissue. These chemically induced injuries are commonly referred to as "chemical burns."
- Such effects are produced not only by strong acids or bases in harmful concentrations, but also by exposure to concentrated solutions of organic solvents such as ether, chloroform or carbon tetrachloride. The intensity of such non-specific toxicity is directly related to the concentrations of the chemical agents when in contact with the target tissues.
- Widespread cell destruction can be caused by any chemical that is sufficiently soluble in tissue fluids to access cells at high concentrations. The effects of these chemicals in higher organisms are generally limited to easily accessible tissues such as the skin, eyes, mouth, nasal mucosa, and respiratory tract.
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Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
About a pound
Explanation:
7 days * 500 cal / day = 3500 cal <==== about a pound of fat cals
There are 2 main processes to test tablet hardness: compression testing and 3 point bend testing. For compression testing, the analyst generally aligns the tablet in a repeatable way, and the tablet is squeezed between a fixed and a moving jaw. The first machines continually applied force with a spring and screw thread until the tablet started to break. When the tablet fractured, the hardness was read with a sliding scale.
