Answer and explanation;
-The insulin receptor itself has decreased kinase activity leading to fewer binding sites for singling effectors to become activated.
Therefore; the signaling effectors are less likely to be activated.
-Additionally,, feedback inhibition decreases signaling effector binding to receptor.
-The lack of activation of these initial signaling effectors prevents any subsequent steps from happening.
-We can thus conclude this by saying that higher insulin concentrations are necessary to obtain the same level of signaling leading to physiological effects that would exist in someone without type-2 diabetes.
-Also the requirement for higher insulin concentration means that the cells that respond to insulin are resistant to its effect.
A) Rest and motion are relative terms
Answer:
Arthroplasty
Explanation:
The restoration of function of a joint is called Arthroplasty. The bone functions are restored by maintaining the bones through resurfacing. Some times artificial joints are also used instead of resurfacing the existing bones.
Arthroplasty is a method to cure Osteoarthritis, or degenerative joint disease where joint cartilages reduces with age.
Also when medical treatments no longer make any impact on the joints of bone pain then Arthroplasty is done.
Endocrine system is the answer
