Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
The answer is D. 4 because its after perception
Answer:
ATP acts as an allosteric inhibitor to many of the enzymes involved in metabolism, thus slowing their function.
Explanation:
JM~ Hope this helps you out.....
The respiratory system works with the digestive and circulatory systems to make cellular respiration possible. During cellular respiration, your cells use oxygen and glucose to release energy. Carbon dioxide is a waste product of the process. Carbon dioxide must be removed from cells.
Info from: Google lolz.
Answer:
Option B, 
Explanation:
Given-
The average surface area of one foot pad of an elephant is

Weight of an Asian elephant is
newton
As we know, pressure is equal to total weight divided by total area of the surface on which it is concentrated.
Thus, pressure on one foot pad of elephant is 

Hence, option B is correct answer