Answer:
Examples of paradigm shifts are the movement of scientific theory from the Ptolemaic system (the earth at the centre of the universe) to the Copernican system (the sun at the centre of the universe), and the movement from Newtonian physics to the theory of relativity and to quantum physics.
Explanation:
Cholesterol (especially LDL*) tend to get into macrophages which migrate into blood vessels. Macrophages with cholesterol cannot get out of the vessels and stay there which causes a lipid mass in arteries. That causes atherosclerosis.