Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
To learn more about axonal transport,
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My answers would be as follows:
<span>1. The humanistic approach emphasizes __________ in development and behavior.
-free will
2. which humanistic theorist developed a hierarchy of needs?
-Abraham Maslow
3. Another way to characterize humanistic psychology is its emphasis on _________.
-the self
4. Which of the following is primary, or must be met first, in Maslow’s hierarchy?
-physiological needs
5. Using you prior knowledge about developmental theory as a guide, which of the following best supports Maslow's assertion that love is a need that is essential to survival.
-Without the opportunity for “love” in the form of contact comfort, people are unable to form attachments, often lead difficult, maladaptive lives, and sometimes fail to thrive at all
Hope this helps. Have a nice day.</span>
Answer:
Two gametes end up with 30 chromosomes, one gamete will have 31 and one will have 29.
Explanation:
During meiosis, a single diploid cell divides into four haploid cells with half the chromosome number than the parent cell.
During meiosis I, homologous chromosomes separate and the chromosome number in the two daughter cells goes down by half. During meiosis II, the "sister" chromatids separate, and the chromosome number in the respective daughter cells remains the same.
Non-disjunction of a single dyad in meiosis II causes that one of the daughter cells will have an extra chromosome, and another will be lacking one. The two other gametes will be normal.
I drew a simple example of what would happen during meiosis of a 2n=4 cell if there was non-disjunction in a single dyad during meiosis II.
