Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.
Protozoa have been classified into three trophic categories: the photoautotrophs which harness the sun's radiant energy in the process of photosynthesis; the photoheterotrophs, which although phototrophic in energy requirements, are unable to use carbon dioxide for cell synthesis and must have organic carbon compounds
I'm not a biologist, so I don't know the actual answer. But my best guess is that there is more in fruits and vegetables than just simple sugars or even complex carbohydrates. There are vitamins for example. Some of the vegetables have simple proteins which are much easier to break down that the complex ones found in meat.