All categories

3 years ago

What bio chemical reactions are altered due to Down syndrome

Biology

1 answer:

ryzh [129]3 years ago

5 0

Answer:

Abstract

Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.

You might be interested in

Where did the Vernon war take place?

Leno4ka [110]

Explanation:

nayarghat

ashok seven live in Chitwan

4 0

2 years ago

Read 2 more answers

What will happen to the population of dolphins if the sharks die out?

Anestetic [448]

Answer::

Explanation::

5 0

3 years ago

Read 2 more answers

Three of the statements below are true statements and one is false. Select the FALSE statement.

kobusy [5.1K]

I would say New genetic combinations occur in body cells that can be passed on to offspring because there won’t be new genetic combinations from body cells that are fully developed.

8 0

3 years ago

Hemophilia is Xlinked recessive trait .Consider a cross between a women who is carrier and man who suffers from hemophilia,Which

lozanna [386]

Answer:

II and III

Explanation:

I. All sons of these parents will be a hemophiliac.

II. A son who suffers from hemophilia received the hemophilia allele from his mother.

III. Half of the daughters of this cross are predicted to be hemophiliacs.

Assuming the haemophilia allele is represented by h, the alternate form being H.

A woman that is a carrier will have the genotype $X^H X^h$ .

A man who suffers from haemophilia will have the genotype $X^h Y$

Crossing both of them:

$X^H X^h$ x $X^h Y$ = $X^H X^h, X^H Y, X^hX^h and X^hY$

From the result of the cross, the following can be deduced:

Half or 50% of the sons from the couple will be haemophiliacs.
Any son that suffers from haemophilia received the allele from the mother.
Half or 50% of the daughters from this cross will be hemophiliacs.

Hence, statements II and III are true.

5 0

4 years ago

Read 2 more answers

How do viruses collect and use energy

Alchen [17]

Answer:

Metabolism means the ability to collect and use energy. ... Viruses are too small and simple to collect or use their own energy – they just steal it from the cells they infect. Viruses only need energy when they make copies of themselves, and they don't need any energy at all when they are outside of a cell.

3 0

4 years ago