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eduard
3 years ago
7

What bio chemical reactions are altered due to Down syndrome

Biology
1 answer:
ryzh [129]3 years ago
5 0

Answer:

Abstract

Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.

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Yuri [45]

Answer:

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Explanation:

Embryology is a discipline that studies the structural/anatomical features and development of embryos. Embryos are a fundamental piece of evidence to support common ancestry among vertebrates because there are homologous structural features that can only be observed during the first stages of vertebrate development. For example, all vertebrate embryos (e.g., fish, chicken and human embryos), develop tails and gill slits during their first stages of embryo development. In consequence, embryology provides evidence for evolution of vertebrates.

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Read more about Zoo here brainly.com/question/27957799

#SPJ1

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2 years ago
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Hope this helped! :D
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