1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
eduard
3 years ago
7

What bio chemical reactions are altered due to Down syndrome

Biology
1 answer:
ryzh [129]3 years ago
5 0

Answer:

Abstract

Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.

You might be interested in
Describe the structure of the cell membrane and explain what materials enter and leave the cell and how each transport method is
Nutka1998 [239]
THE STRUCTURE OF THE CELL MEMBRANE
the cell membrane is a thin layer of a partially permable membrane. That protects the cell's organelles and helps to maintain the shape of the cell.
WHAT MATERIALS ENTER OR LEAVE THE CELL MEMBRANE.
since the cell membrane is partially permable, that it only allows some materials to pass through it only nutrients that need to be metabolized or neede by the cell is allowed or permitted to go in the cell either by diffusion or osmosis.
HOW IE ONE METHOD DIFFRENT FROM THE OTHER?
since diffrent materials that go in the cell have different concentrations, sizes, and weights, the method by which they go into the cell will definately be diffrent materials with larger molecules use the osmosis method to go in the cell, while materials with smaller molecules use the diffusion method. I HOPE THIS REALLY HELPED
3 0
3 years ago
The lines on a fingerprint circle around a central point. What is the pattern of this fingerprint? A. Swirl B. Bank C. Loop D. V
Sladkaya [172]
The Answer is C. Loop. I hope this help.
8 0
3 years ago
Serves as the molecular basis for life. DNA copies itself via the process of . RNA is produced from DNA via the process of . Pro
blagie [28]

Answer:

CGTCATC

Explanation:

In a DNA double helix, the complementary bases of two strands of DNA are paired by hydrogen bonds. Adenine of one DNA strand is paired with the thymine of the other strand. Similarly, the guanine of one DNA strand is paired with the cytosine of the other DNA strand. If a portion of one of the two strands of a DNA molecule has the sequence GCAGTAG. The sequence of the other strand would be as following:

One DNA strand: GCAGTAG

Other DNA strand: CGTCATC

8 0
3 years ago
How are mutations prevented during DNA replication?
Ulleksa [173]
B. trna molicules check the amino acid for errors

3 0
3 years ago
Read 2 more answers
The cell cycle includes four phases-- G1, S1, G2, and M. What occurs during the S phase?
LekaFEV [45]

Answer:

In S phase, the cell synthesizes a complete copy of the DNA in its nucleus. It also duplicates a microtubule-organizing structure called the centrosome.

Explanation:

7 0
3 years ago
Read 2 more answers
Other questions:
  • In a science experiment, equal-sized populations of two species of earthworms are placed in a terrarium filled with soil. Abioti
    5·1 answer
  • Occurs when the body receives antibodies from another source, such as a child receiving antibodies from its mother
    6·1 answer
  • Can someone tell me if I explained this right?
    11·1 answer
  • Which statement is true about body temperature?
    7·2 answers
  • The viscosity of magma depends upon its silica content and its
    8·1 answer
  • The field of conservation biology ________.tries to increase speciation events in order to increase biodiversitydeveloped in res
    8·1 answer
  • List your favorite food chain/web, with examples and its environment.​
    9·1 answer
  • What is the Kreb Cycle and what happens during that stage in the cellular respiration?
    13·1 answer
  • Who created the naming system
    5·2 answers
  • The image below shows plant cells. plant cells What feature of cells is best demonstrated in the image? A. All organisms have ce
    13·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!