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eduard
3 years ago
7

What bio chemical reactions are altered due to Down syndrome

Biology
1 answer:
ryzh [129]3 years ago
5 0

Answer:

Abstract

Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.

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astraxan [27]
1.The trait is recessive. This means both your parents were carries, but did not show the trait. For example, B represents the allele, you're parents would have to both be Bb. This means that they are carriers, and you could have inherited either BB/Bb/bb - you actually inherited bb, which means because its a recessive trait you will show the trait. 

2. For your children, it depends on who you have them with. Because you're bb, you will definitely pass on the b allele, so any child you have would be a carrier and could potentially have the trait. If you have a child with someone BB, all your offspring will be Bb (carriers- as the kid gets one allele form each parent). If you have a child with someone who is bb, all your kids would definitely have the trait. However, if you have a child with someone who as Bb, then the four outcomes are Bb Bb bb bb, so there would be a 50% chance of your kid having the trait.



Hope this helps!! :)


8 0
4 years ago
Which of the following is a true statement about sexual vs. asexual reproduction?
yuradex [85]
A. Would be the correct answer!
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vichka [17]

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3 years ago
An operon encodes enzymes for making an essential amino acid and is regulated like the trp operon. Which of the statements is tr
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Answer:

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Explanation:

So since they are normal but their son isn't it is assumed that the mom is the carrier since the dad has to be X^HY

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8 0
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