1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
eduard
2 years ago
7

What bio chemical reactions are altered due to Down syndrome

Biology
1 answer:
ryzh [129]2 years ago
5 0

Answer:

Abstract

Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.

You might be interested in
What is the essence of the catalase test?
garik1379 [7]

Explanation:

Catalase test demonstrate the presence of an enzyme called catalase, that catalyses the release of oxygen from hydrogen peroxide. It is used to tell the difference between the non-catalase producing bacteria from those bacteria that produces an enzyme catalase. Catalase is produced by the bacteria that respire using oxygen. If an organism produces catalase, bubbles of oxygen are produced when hydrogen peroxide is added to it.

8 0
2 years ago
What reflects both genetic and environmental influences?
solong [7]
An individuals phenotype
4 0
3 years ago
Explain three ways in which red blood cells are adapted to their function​
Salsk061 [2.6K]

Answer:

Red blood cells are adapted to their function by:

1) They contain haemoglobin - a red protein that combines with oxygen. they have no nucleus so they can contain more haemoglobin.

2) They are small and flexible so that they can fit through narrow blood vessels.

3) They have a biconcave shape (flattened disc shape) to maximise their surface area for oxygen absorption.

Hope this helps! :D

8 0
3 years ago
Read 2 more answers
When h forms a bond with h2o what bond is it making ?
Reil [10]

When h forms a bond with h2o to form hydronium ion, h3o , this bond is called a coordinate covalent bond.

4 0
3 years ago
Which other type of energy
Damm [24]

Answer:

computers do not produce energy they consume energy

7 0
3 years ago
Read 2 more answers
Other questions:
  • PLEASE HELP EARTH SCIENCE! BRAINLIEST TO FIRST CORRECT ANSWER
    5·2 answers
  • I need help labeling this diagram please
    12·1 answer
  • Study these diagrams. The dots represent valence electrons orbiting the nucleus of an atom. Which diagram shows the valence elec
    12·2 answers
  • In what industry do fertilizers and pesticides wash off and contaminate water supplies?
    14·1 answer
  • Single celled microorganisms are sometimes called simple organisms why is this inaccurate
    12·2 answers
  • The rebirth of science and learning during the fifteenth century is termed the?
    14·2 answers
  • What is the fluid inside a cell
    6·2 answers
  • What is the answer to this?
    6·1 answer
  • 6. Can I sell my organs? Why or why not?
    13·1 answer
  • Name the type of connective tissue that anchors the ribs onto the sternum.
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!