Answer:
The Various Kinases that is activated after the breaks in DNA is after the activation of ATM serine threonine kinase which helps in phosphorylation of other DNA replication check proteins, p53 protein (tumor suppressor protein) etc.
Explanation:
ATM activated by MRN complex at the site of DNA double stranded breaks by phosphorylation. MRN complex activity on ATM induces a conformational change in ATM kinase. So it can bind to its various substrate molecules that helps in DNA replication cycle arrest.
ATM phosphorylates CHK2 protein a product of CHEK2 gene, also known as effector kinases that phosphorylates and helps in deactivation of cyclin dependent kinases (CDKs) that helps in the prevention of progression of mitotic phase.
ATM also phosphorylates the inhibitors of p53 proteins which leads to the overexpression of p21, an inhibitor of (CDKs).
The cardiovascular and immune
Osseous Tissue<span>. </span>Bone<span> consists of bony connective tissue called ______. Compact</span>Bone<span>. </span>Bones<span> consist of a smooth, </span>dense<span> outer layer called ______ and an internal .... Around the </span>circumference<span> of the </span>bone<span>, just deep into the periosteum.</span>
~Hello there!
Your question: What substance is considered a building block for all living things?
Your answer: Carbon is the substance that is considered s building block for all living things.
Any questions ^?
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