It would be D discrimination. High blood pressure and shortened lifespan would be physical obesity problems but discrimination would be psychological. An obese person often feels that other stare at them or treat them differently. This has a large impact on mental health as well.
If ΔG is negative, the reaction is always spontaneous. If ΔG is positive, the reaction is non-spontaneous and will require a sustained input of energy for it occur. If ΔG is zero, the reaction is at equilibrium and no work can be done.