Well, if we are talking about the black death? A reaction that they did was they all went into hiding because they thought that the black death was an angel or something targeting certain families, they were right it was something but it was just a virus that almost killed an entire country!!
It is false that is gave cherokees permission to attack anyone who settled on thier land. The trail of tears actually were taken from thier land hundreads of miles to a reserve on the trail of tears.
I believe it’s option c or the last one sorry if I’m incorrect