Answer:
Constitutive activation is the alteration of a protein or signaling pathway such that it is functional or engaged even in the absence of an upstream activating event. For example, RasD is constitutively active because it cannot bind GAP and therefore remains in the GTP-bound, active state even when cells are not stimulated by growth factor to activate a receptor tyrosine kinase.
Constitutively active Ras is cancer promoting because cells will proliferate in the absence of growth factors, and thus normal regulatory mechanisms for cell proliferation are bypassed.
(a) A mutation that resulted in Smad3 binding Smad4, entering the nucleus, and activating transcription independent of phosphorylation by the TGFβ receptor would render Smad3 constitutively active.
(b) A mutation that made MAPK active as a kinase and able to enter the nucleus without being phosphorylated by MEK would render MAPK constitutively active.
(c) A mutation that prevented NF-KB from binding to IK-B or that allowed NF-KB to enter the nucleus and regulate transcription even when bound to IK-B would render NF-KB constitutively active.
Answer:
Mutation. A mistake made while DNA copies which causes changes in DNA
Explanation:
Answer: The answer is D Increasing climate change
Explanation: Which of the following is a direct benefit of using agriscience to optimize land use for animal grazing? hope this helps man
After 20 years a resorted wetland can contain approx. 80% of plant biomass of a natural wetland.
Wetlands are one of the most endangered ecosystems in the world according to the UN and restoration is the only way to save these habitats.
The fact that restored wetlands can contain up to 80% of plant biomass shows how successful restoration programs can be.
Answer:
To determine the effect of toxin binding, you perform a Competitive Binding Experiment
Explanation:
Competitive binding experiments are very relevant when matters relating to cellular and or molecular toxicity are concerned.
They are used to determine the binding of a single concentration of labeled ligand in the presence of various concentrations of unlabeled ligand.
They are important because:
1. Validate a direct binding assay
2. Confirm whether or not a drug binds to the receptor
3. determine and explore how low-affinity drugs and receptors interact and it's resultant effects
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