I’m not sure this is a tough question!!
Answer:
When seen on a Wright-stained peripheral blood film, a young red cell that has just extruded (lost its) nucleus is referred to as a polychromatophilic cell.
Explanation:
On Wright-stained smears, slightly immature red cells that do not have nuclei (reticulocyte stage) look blue-gray because they still have some ribonucleic acid in them (RNA). These cells are commonly referred to as polychromatophilic cells. Most of the time, polychromatophilic cells are bigger than mature red cells, and their blue-gray color makes them different from macrocytes. Polychromatophilic red cells also tend to lack the central pallor.
When the remaining mRNA and ribosomes are stained with supravital dyes, they make the red cells look like a "reticular" mesh network. This is how the name "reticulocyte" came about. It is to be noted that not all reticulocytes show up as polychromatophils when stained with Wright-Giemsa.
Learn more about peripheral blood smear here:
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