<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
Answer:
The activity of cyclic AMP phosphodiesterase is prevented by caffeine. The caffeine prevents further dissociation of cAMP, which eventually increases the response within the body. The activity of neurotransmitters, that is, of noradrenaline or epinephrine, gets increased due to enhancement in response.
This further enhances the activity of the heart, the rate of muscle contractions, blood pressure that further helps in delivering more oxygen to the brain, and other parts of the body. Thus, the inhibition of the enzyme cyclic AMP phosphodiesterase helps the athletes to prevent the wall.
Answer: Eating a diet high in saturated fats, trans fats, and cholesterol has been linked to heart disease and related conditions, such as atherosclerosis. Also too much salt (sodium) in the diet can raise blood pressure. Not getting enough physical activity can lead to heart disease.
Explanation: Diet is an important risk factor in coronary heart disease. Heavy drinking may well increase heart attack, heart failure, stroke, and high blood pressure. A limit for men is 2 drinks a day, for women 1 drink a day.
Answer:
72, because you just multiply by 2
Arthritis is a joint disorder involving joint inflammation.Pain is often localized to only the affected joint. Osteoarthritis is a wear and tear type of arthritis often affects aging population affecting joints in hands,knees and lower back. Heberden's node is an example and develops around middle age thus Wendell might have this.
