Answer:
Explanation:
a. Since both the parents are carriers, they have one allele that is the gene for the normal trait and one gene that is for the sickle cell trait. So the genotypes of the parents are Hh
b. If we use a punnett square:
H h
H HH Hh
h Hh hh
Genotypic ratio: 1 HH: 2Hh: 1hh
Phenotypic ratio: 1 normal blood cell: 2 sickle cell carriers: 1 sickle cell disease
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
Learn more about Parkinson's disease brainly.com/question/28169444
#SPJ4
Answer: C; <em><u>Testes</u></em>
<em><u>Hope this helps </u></em>
<em><u><3</u></em>
<em><u>-Carrie</u></em>
<em><u>P.S. It would mean a lot if you marked brainliest </u></em>
<em><u>Stay Safe </u></em>
This is gravity.
Gravity is a force that is exerted on all objects on earth. The greater the mass, the greater the force of gravity is on an object.
Nuclear DNA is present in the nucleus of eukaryotic cells. When working with the DNA samples, the best source of nuclear DNA is hair root that anchors the whole shaft of hair. Hair root possesses cells that are called as keratinocytes.
